Summary of semiquantitative data revealed by immunocytochemistry
| Structure labeled | Wildtype | TrkA (−/−) | TrkB (−/−) | |
|---|---|---|---|---|
| Neuropeptides | ||||
| Neuropeptide Y | Chromaffin cell subpopulations (2) | ++ | +++ | +++ |
| Somatostatin | Chromaffin cell subpopulation | + | + | + |
| Met-enkephalin | Chromaffin cell subpopulation | + | + | + |
| Galanin | Chromaffin cell subpopulation | ++ | ++ | ++ |
| Innervation | ||||
| Synaptophysin | Fiber innervation | ++ | + | + |
| L1 | Fiber innervation and extracellular labeling | ++ | ++ | ++ |
| Catecholamine synthesizing enzymes | ||||
| TH | Chromaffin cell subpopulations (2) | +++ | +++ | +++ |
| PNMT | Chromaffin cell subpopulation | ++ | ++ | ++ |
| Vesicular | ||||
| Chromogranin B | Chromaffin cell subpopulation | ++ | + | + |
| Secretogranin II | Chromaffin cell subpopulation | ++ | ++ | ++ |
| VMAT-1 | All chromaffin cells | + | + | + |
| VMAT-2 | Chromaffin cell subpopulation | + | + | + |
* Denotes the apparent degree of labeling: +++ strong, ++ moderate, + weak.