Table 1.

Peak and steady-state whole-cell currents and desensitization time constants in the presence of 100 μmGYKI 53655

AgonistPeak I pASteady state,1-a(%)τ11-b msecAmp 11-c (%)τ21-b msecAmp 21-c (%)n
Kainate (300 μm)−649  ± 4227  ± 227  ± 378  ± 3405  ± 3122  ± 321
Glutamate (1 mm)−831  ± 1428  ± 138  ± 496  ± 1393  ± 674  ± 115
SYM 2081 (500 μm)−698  ± 1026  ± 228  ± 398  ± 1391  ± 992  ± 114
  • All values are mean ± SEM. The holding potential was −90 mV.

  • F1-a  Steady-state current at the end of a 2 sec application as a percentage of the initial peak.

  • F1-b  Time constants for the best fit of two exponentials to the decaying component of current.

  • F1-c  Fractional amplitude of each exponential component as a percentage of the total decay.