Table 1.

Effect of seven daily intraperitoneal administrations of saline or cocaine on horizontal activity in the rat

nDay 11-aDay 7Statistics1-b
Amphetamine
 Saline137973 (658)1-c9907 (2032)t(12) = 0.929, p  = 0.3711
 Cocaine1211513 (1464)20039 (2565)t(11) = 02.39, p  = 0.0358
GBR-12909
 Saline94747 (467)7588 (1063)t(8) = 02.42, p  = 0.0422
 Cocaine813119 (2159)25159 (3574)t(7) = 03.04, p  < 0.0188
Amphetamine + verapamil
 Saline74002 (627)6840 (533)t(6) = 03.45, p  = 0.0136
 Cocaine914402 (1627)25123 (1755)t(8) = 09.14, p  = 0.0001
Amphetamine + diltiazem
 Saline104035 (1036)5322 (762)t(9) = 01.14, p  = 0.2822
 Cocaine1013738 (2212)19085 (7247)t(9) = 02.99, p  = 0.0153
Amphetamine + ω-conotoxin
 Saline104419 (360)5627 (907)t(9) = 01.36, p  = 0.2064
 Cocaine813460 (2352)21193 (3793)t(7) = 02.55, p  = 0.0382
Botulinum toxin–amphetamine
 Saline75894 (1029)6418 (1164)t(6) = 0.452, p  = 0.6673
 Cocaine1015096 (3380)21260 (4325)t(9) = 01.30, p  = 0.2265
Botulinum toxin–GBR-12909
 Saline63466 (146)5962 (1245)t(5) = 01.89, p  = 0.1168
 Cocaine611826 (4786)32261 (4093)t(5) = 07.66, p  = 0.0006
Amphetamine + KN-93
 Saline93739 (551)7578 (1438)t(8) = 02.53, p  = 0.0351
 Cocaine89266 (2345)21481 (2472)t(7) = 04.28, p  = 0.0036
Amphetamine + KN-92
 Saline97025 (902)5583 (911)t(8) = 01.13, p  = 0.2935
 Cocaine816799 (3311)22599 (4717)t(7) = 01.14, p  = 0.2900
GBR-12909 + KN-93
 Saline115928 (953)9270 (1324)t(10) = 02.16, p  = 0.0558
 Cocaine1612376 (1975)19257 (2643)t(15) = 01.93, p  = 0.0729
  • F1-a Cocaine or saline was administered daily for 1 week. Day 1 corresponds to the first and day 7 the last daily injection. Horizontal activity was measured on days 1 and 7 after an intraperitoneal injection of cocaine (15 mg/kg) or saline. On days 2–6, the subjects received an intraperitoneal injection of either cocaine (30 mg/kg) or saline and were returned to their home cage.

  • F1-b Paired t test; degrees of freedom in parentheses.

  • F1-c The data are presented as the total horizontal photocell counts (SE) recorded over the first 120 min after cocaine or saline injection.