Table 2.

Gating properties of inward rectifier currents in wild-type and weaver granule cells

Gmax(nS)Vrev (mV)V1/2(mV)k (mV−1)
G–IIR (n = 8)2.6  ± 1.6−80.5  ± 6.6*−81.9  ± 8.325.1  ± 5.7**
C–IIR (n = 7)1.4  ± 1.2−84.2  ± 7.7**−86.3  ± 7.28.1  ± 0.7*
wv–IIR (n = 6)4.3  ± 2.6−64.1  ± 6.3−71.6  ± 1.911.6  ± 1.4
  • Average parameter values characterizing inward rectifier current activation were obtained using Equation 1. The reversal potential (Vrev) was significantly less negative inwv–IIR than in eitherC–IIR (**p < 0.01) orG–IIR (**p < 0.002). The voltage-dependence of activation (k) was significantly different in wv–IIR as compared withC–IIR (*p < 0.01) andG–IIR (**p < 0.001). Once the maximum conductance (Gmax) was normalized for the membrane capacitance, the sequence G–IIR(0.68 ± 0.4 nS/pF) > wv–IIR (0.56 ± 0.3 nS/pF) > C–IIR (0.41 ± 0.33 nS/pF) was obtained, with wv–IIR proving to be statistically indistinguishable from C–IIR orG–IIR.