Effect of neurotransmitter antagonists on the inhibitory modulation of neuronal activity
| Condition | Control | Antagonist | Recovery |
|---|---|---|---|
| Inhibitory neurotransmitter antagonists | |||
| Bicuculline (5 μm) | −31 ± 5% (15) | −13 ± 3% (17)* | −26 ± 3% (16)* |
| Strychnine (1 μm) | −28 ± 5% (20) | −8 ± 3% (17)* | −25 ± 4% (19)* |
| Bicuculline + strychnine | −28 ± 4% (28) | 0 ± 1% (23)* | −20 ± 2% (32)* |
| Glutamate antagonists | |||
| NBQX (10 μm) | −25 ± 5% (22) | −6 ± 3% (22)* | −15 ± 2% (23)* |
| D-AP7 (200 μm) | −24 ± 5% (21) | −12 ± 4% (18)** | −22 ± 5% (14) |
| NBQX + D-AP7 | −18 ± 2% (19) | −2 ± 2% (19)* | −12 ± 3% (18)* |
Shown are the average modulation values for trials when a Ca2+ wave reached the neuron. Only neurons with significant inhibitory modulation were tested. Antagonists were applied for 15 min before testing. Recovery followed a 60 min washout.
* p < 0.01, antagonist versus control, recovery versus antagonist.
** p < 0.05.