Table 1.

Striatal culture thickness as measured by the depth distribution of striatal TH-ir fibers and number of nigral TH-ir neurons per group for the combined mGluR agonist/antagonist experiments

Normal1S,3R-ACPD (100 μm)l-AP3 (100 μm)1S,3R-ACPD (100 μm) + l-AP3 (100 μm)Normal1S,3R-ACPD (1000 μm)l-AP3 (100 μm)1S,3R-ACPD (1000 μm) + l-AP3 (100 μm)
Number of cultures1618181815141713
Striatal culture thickness (μm)126.8  ± 2.3*27.7  ± 2.2*22.9  ± 3.1*19.6  ± 1.7*22.8  ± 3.0†25.0  ± 2.5†23.8  ± 3.5†19.6  ± 2.5†
Number of TH-ir nigral neurons2305  ± 87**270  ± 64**247  ± 65**252  ± 63**367  ± 561-164488  ± 521-164402  ± 1031-164409  ± 761-164

  • Not significantly different: *F = 2.29;p = 0.09; df = 3,66; **F = 0.14;p = 0.94; df = 3,68;

  • ↵† F = 0.53; p = 0.66; df = 3,55;

  • ↵F1-164 F = 0.42;p = 0.74, df = 3,55.