Table 1.

Striatal energy metabolites in creatine- and cyclocreatine-fed animals (μmol/gm wet weight)

	Control	Creatine	Cyclocreatine	Control with 3-NP	Creatine with 3-NP
Creatine	9.07 ± 0.52	9.68 ± 0.43	5.60 ± 0.09*	4.91 ± 0.76*	7.88 ± 0.61**
Lactate	3.08 ± 0.51	2.72 ± 0.33	3.40 ± 0.62	14.05 ± 3.02*	8.75 ± 2.14***
PCr, PCCr^1-a	1.64 ± 0.20	2.70 ± 0.29*	53.5 ± 2.5*	0.62 ± 0.16****	1.14 ± 0.17***
GDP	0.23 ± 0.02	0.24 ± 0.02	0.21 ± 0.01	0.07 ± 0.01*	0.17 ± 0.02**
AMP	0.91 ± 0.08	0.96 ± 0.06	0.79 ± 0.02	0.35 ± 0.06*	0.65 ± 0.12*****
NAD	1.06 ± 0.07	0.97 ± 0.05	0.91 ± 0.03	0.41 ± 0.09*	1.01 ± 0.14**
ADP–GTP	0.71 ± 0.03	0.79 ± 0.04	0.77 ± 0.02	0.23 ± 0.05*	0.64 ± 0.07**
ATP	1.23 ± 0.18	1.38 ± 0.17	1.50 ± 0.10	0.31 ± 0.10*	0.99 ± 0.19*****

n = 8–10 animals per group.
↵F1-a Values are PCr, except for after feeding with cyclocreatine, when they are PCCr.
*P < 0.001; ****P < 0.01 compared with control.
**P < 0.001; ***P < 0.05; *****P < 0.01 compared with control with 3-NP.