Table 1.

Actions of noradrenaline (NA) or 6-fluoronorepinephrine (FNE) on identified GABAergic cell types

GABA cell typenCell characteristicsAdrenergic responses
Resting potential (mV)Input resistance (MΩ)Cross-sectional somaticNA (10–50 μm) (number of cells)FNE (10–50 μm) (number of cells)Spike firing1-a (firing cells/ total in CNQX/APV)
Area (μm2)Longest extent (μm)DepoHyper/ DepoDepoHyper/DepoHyper
FS cells36−70.1  ± 4.9144  ± 38151  ± 3717.1  ± 2.89270/28 (0%)
LS cells7−62.3  ± 4.7184  ± 51144  ± 6016.2  ± 3.6610/6 (0%)
SOM RSNP cells21−53.4  ± 3.2332  ± 100202  ± 6019.7  ± 3.34115112/13 (92%)
SOM BSNP cells3−50.7  ± 4.9400  ± 39176  ± 9618.3  ± 3.121
CCK RSNP cells22−52.6  ± 27.0360  ± 102250  ± 5922.8  ± 4.2716626/15 (40%)
CCK BSNP cells4−58.0  ± 2.7697  ± 284225  ± 4322.4  ± 4.242/4 (50%)
  • The solution contained CNQX/APV, TTX or both. Data are mean ± SD. n, Number of cells; Depo, depolarization; Hyper/Depo, hyperpolarization followed by depolarization; Hyper, hyperpolarization; FS, fast-spiking; LS, late-spiking; RSNP, regular-spiking nonpyramidal; BSNP, burst-spiking nonpyramidal; SOM, somatostatin; CCK, cholecystokinin.

  • F1-a Proportion of cells that fired spikes in response to NA or FNE application in a solution containing CNQX/APV but not TTX.