Table 3.

Results from dose–response simulations

ConditionsDose vs PoDose vs flux
(1) vary [Gluout]
K  = 3  μmK  = 3.1  μm
[Na+out] = 146 mm
[K+in] = 140 mmn  = 1n  = 1
[Na · Gluin] = 10 mm
(2) vary [Na+out]
K  = 14  mmK  = 22  mm
[Gluout] = 30 μm
[K+in] = 140 mmn  = 2.6n  = 1.8
[Na · Gluin] = 0 mm
(3) vary [H+out]
K  = 4.1  nmK  = 2.4  nm
[Gluout] = 100 μm
[Na+out] = 146 mmn  = 1.3n  = 1
[K+in] = 140 mm
[Na · Gluin] = 10 mm
(4) vary [K+out]
K  = 27  mmK  = 25  mm
[Gluout] = 0 μm
[Na+out] = 80 mmn  = 1.1n  = 1
[K+in] = 0 mm
[Na · Gluin] = 10 mm
  • Dose dependencies for glutamate, Na+, H+, or K+ ions were simulated for steady-state Po or steady-state flux under the indicated conditions. An equation of the form: Embedded Imagewas fit to simulated [ion] versus response relationships where K and n were allowed to vary, and Rmax was fixed at the maximal response value. In all conditions pHin was set at 7.3; in all conditions except (3), pHout was 7.4; and in all except (4), [K+out] was set at 2.5 mm.