Table 2.

Properties of action potentials in E16 cultured hippocampal neurons

ControlNeurotrophins
Threshold (mV)−29.40  ± 1.10−32.1  ± 1.16**
Rise time (msec)1.73  ± 0.101.46  ± 0.07**
Peak amp (mV)81.45  ± 6.5094.01  ± 3.60**
Decay time (msec)3.90  ± 0.612.68  ± 0.22**
AP width (msec)5.63  ± 0.694.14  ± 0.19**
AHP amp (mV)10.90  ± 1.4510.03  ± 0.91
  • Action potentials elicited in response to a glutamate pulse were recorded under current-clamp mode from E16 hippocampal neurons cultured for 14 d in the presence or absence of BDNF plus NT-3. Data are presented as mean ± SEM of 12 control neurons or 13 neurotrophin-treated neurons. **p < 0.01 vs control values using Student’s t test. amp, Amplitude; AP, action potential; AHP, afterhyperpolarization.