Table 1.

Affinity values of μ-, δ-, and κ-opioid agonists in 129/SV x C57B1/6 mice

μδκ
DAMGO1.341-a5402180
Morphine3.15221121
Deltorphin II14880.361-b>100000
DPDPE7421.8>100000
CI-9771659720.211-a
U-50,488H837145002.0
  • Opioid receptor sites were labeled using [3H] DAMGO (μ), [3H] naltrindole (δ), and [3H] CI-977 (κ), and Ki values were determined by competition experiments. Affinity values (nm) are means from at least two separate experiments.

  • F1-a From Matthes et al. (1996).

  • F1-b Determined by Scatchard analysis of [3H] deltorphin II binding.