Table 1.

Comparison of currents evoked at subsaturating and saturating concentrations of baclofen and 2-chloroadenosine in eight cells

CellIBac (1 μm) (pA)IAden (150 nm) (pA)IBac+Aden (1 μm Bac, 150 nm Aden) (pA)Supra-additivity (%)IBac (100 μm) (pA)IAden (10–100 μm) (pA)IBac+Aden (100 μm Bac, 10–100 μm Aden) (pA)Fractional additivity
19327141184131304130
26525111232061202080.02
36232105123041663340.18
4176110339196233447170.27
514094324386904548680.39
6112117309356235099070.56
78838199587822329340.66
81621534375761300.72
  • Supra-additivity at low agonist concentrations determined as 100 × [IBac+Aden−[IBac+IAden]/[IBac+IAden]. Fractional additivity at saturating concentrations determined by the expression [IPairIMax)/IMin.