Table 1.

Comparison of the morphological features of CA3C hippocampal pyramidal cell dendrites and axons in control and experimental rats

ParametersApicalBasilarTotal
ControlExperimentalControlExperimentalControlExperimental
n666666
Dendrites
 Spine density (number/100 μm)1-a46.2  ± 2.536.5  ± 5.3**49.5  ± 4.731.6  ± 6.4***47.8  ± 2.834.0  ± 4.9***
 Diameter1-a
  Minimal (μm)0.40  ± 0.080.18  ± 0.04***0.37  ± 0.070.24  ± 0.04**0.39  ± 0.070.22  ± 0.04***
  Maximal (μm)0.50  ± 0.140.26  ± 0.06**0.43  ± 0.080.29  ± 0.07**0.47  ± 0.110.28  ± 0.06**
 Thorny excrescences
  Number6.50  ± 1.392.83  ± 1.72**6.00  ± 4.143.83  ± 3.1312.5  ± 4.416.67  ± 4.32*
  Area (μm2)55.9  ± 31.173.7  ± 71.839.0  ± 21.345.8  ± 39.250.6  ± 12.166.4  ± 29.8
 Segment number75.5  ± 26.167.8  ± 25.873.3  ± 16.051.2  ± 13.4*143  ± 35.8124  ± 9.4
 Length (mm)4.64  ± 1.424.43  ± 0.763.96  ± 0.773.01  ± 0.988.60  ± 1.637.45  ± 0.73
Axons
 Length (mm)4.02  ± 1.64.81  ± 3.05.20  ± 1.835.26  ± 2.219.23  ± 2.9510.1  ± 4.49
 Branch number28.0  ± 15.527.5  ± 19.359.8  ± 19.153.2  ± 25.187.8  ± 28.480.7  ± 37.4
 Varicosity number396  ± 215481  ± 302771  ± 422629  ± 2931167  ± 5711111  ± 437
 Varicosity density (number/100 μm)9.38  ± 3.709.97  ± 3.7014.27  ± 3.8311.75  ± 2.2712.02  ± 3.4510.86  ± 1.10
  • F1-a Measures are from terminal order dendritic segments, n = 6. Six neurons were reconstructed in both the experimental and control groups. Data are expressed as mean ± SD.

  • *p < 0.05.

  • **p < 0.01.

  • ***p < 0.001.