Table 2.

Effects of kinase inhibitors on the kinetics of TTX-RI_Na

Test agent	n	T_0.5activation (0 mV)			Tau inactivation (0 mV)			Tau deactivation^2-a % change
Test agent	n	1 min (msec)	10 min (msec)	% Change	1 min (mV)	10 min (mV)	% Change	Tau deactivation^2-a % change
Control	10	0.98 ± 0.04	0.99 ± 0.05	0.5 ± 3.0	4.7 ± 0.2	5.0 ± 0.3	6.7 ± 3.5	−6.9 ± 2.5
PKC_19–36 (10 μm)	6	1.08 ± 0.01	1.09 ± 0.05	1.1 ± 5.8	6.0 ± 0.4	6.0 ± 0.5	−0.4 ± 3.4	3.2 ± 4.1
Staurosporine (1 μm)	7	0.94 ± 0.06	0.97 ± 0.04	4.2 ± 3.2	5.0 ± 0.5	5.5 ± 0.5	10.4 ± 2.0	−12.5 ± 2.1
WIPTIDE (10 μm)	8	0.90 ± 0.07	0.84 ± 0.06	−6.6 ± 1.4	5.1 ± 0.6	4.8 ± 0.4	−1.4 ± 2.2	0.0 ± 4.6
Rp-cAMPs (1 mm)	9	1.00 ± 0.05	0.98 ± 0.04	−1.0 ± 4.1	5.0 ± 0.3	4.8 ± 0.2	−2.5 ± 3.7	1.0 ± 4.4

In this and Table 4, T_0.5 activation is the time from the beginning of the activating voltage step to the point at which TTX-T I_Na had obtained half of its peak amplitude. Tau inactivation and tau deactivation are time constants obtained from fitting, respectively, the inactivating and deactivating phase of TTX-R I_Na with a single exponential function.
↵F2-a Data are pooled for neurons in which the deactivating voltage step was to either −50 or −70 mV, from an activating voltage step to −10 mV.