Table 1.

Parameters of the voltage dependence of activation and inactivation and recovery from inactivation

ChannelActivationInactivationRecovery from inactivation
τ1τ2τ3
V1/2(mV)z(eo)nV1/2(mV)a (mV)nmsec%msec%msec%n
Rat1−17  ± 44.8  ± 0.58−35  ± 25.2  ± 0.561.9  ± 0.634  ± 446  ± 2730  ± 12280  ± 13036  ± 134
Rat1 + β1−18  ± 14.2  ± 0.2*5−43  ± 2*5.1  ± 0.661.1  ± 0.189  ± 1*18  ± 107.1  ± 2.4*ND1-aND1-a3
Rat1 + β2−19  ± 45.1  ± 1.06−37  ± 26.1  ± 0.3*60.9  ± 1.126  ± 645  ± 2546  ± 18ND1-bND1-b5
Rat1 + β1 + β2−15  ± 23.9  ± 0.4*6−41  ± 2*4.8  ± 0.631.4  ± 0.682  ± 1*13  ± 48.6  ± 4.0*ND1-bND1-b4
Rat2−18  ± 55.0  ± 1.210−42  ± 47.4  ± 1.033.3  ± 0.639  ± 9130  ± 2044  ± 9890  ± 36017  ± 55
Rat2 + β1−21  ± 54.7  ± 0.57−52  ± 1*5.3  ± 0.6*71.8  ± 0.2*92  ± 3*26  ± 5*7.8  ± 3.0*ND1-cND1-c4
Rat2 + β2−18  ± 74.4  ± 0.25−45  ± 26.8  ± 0.351.3  ± 0.9*35  ± 560  ± 30*44  ± 8ND1-bND1-b3
Rat2 + β1 + β2−22  ± 44.5  ± 0.45−57  ± 4*4.5  ± 0.3*52.2  ± 0.2*93  ± 1*47  ± 44*3.5  ± 2.3*ND1-aND1-a5
  • *Indicates a statistically significant difference from α subunit alone at p < 0.05.

  • F1-a ND, Not determined because the percentage of current recovering with τ3 was <4%.

  • F1-b ND, Not determined because the time constant was >1 sec and could not be accurately quantified.

  • F1-c ND, Not determined because recovery for these channels was best fit with a double-exponential equation.