Axon number changes (%) in L4 and L5 ventral roots
| Stage | PMW | RD | 20 d | 33 d | 50 d | Para |
|---|---|---|---|---|---|---|
| Total axons | −6.2 | −9.8 | −19.3 | −24.1 | −30.6 | −61.9 |
| Large axons | −19.5 | −23.9 | −47.1 | −45.7 | −52.5 | −86.0 |
| Large → small | 10.9 | 10.3 | 20.2 | 12.1 | 9.9 | 2.8 |
| Degenerated large axons | −8.6 | −13.6 | −26.9 | −33.6 | −42.6 | −83.3 |
The percent reduction in total axon number and large axon number is calculated in reference to wild-type mice. The definition of large and small axons is described in the text (also see Fig. 5). The fraction of large axons that become small (large → small) is estimated by subtracting the small axon number in the wild-type mice from that of the G93A mice at different stages. The difference between the total lost large axons and the fraction of the large axons that become small (large → small) is the fraction of large axons that are degenerated.