Genotype | Total horizontal distance (cm) | Initiation of movement (no) | Time in motion (sec) | Rearing (no) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Saline | Haloperidol | p | Saline | Haloperidol | p | Saline | Haloperidol | p | Saline | Haloperidol | p | ||
129/SvEv | n = 9,9 | 1128 ± 253 | 163 ± 44 | 0.001 | 94 ± 21 | 19 ± 4 | 0.003 | 126 ± 30 | 17 ± 5 | 0.002 | 0.6 ± 0.4 | 0 ± 0 | NS |
−/− | n = 8,10 | 3054 ± 1196 | 2824 ± 544 | NS | 239 ± 82 | 192 ± 39 | NS | 289 ± 96 | 274 ± 42 | NS | 12 ± 6.8 | 9 ± 4 | NS |
+/− | n = 20,17 | 4336 ± 606 | 1239 ± 233 | 0.0002 | 317 ± 41 | 131 ± 24 | 0.0007 | 441 ± 55 | 123 ± 18 | 0.0001 | 49 ± 12 | 7 ± 2.4 | 0.0021 |
+/+ | n = 15,15 | 6222 ± 945 | 590 ± 150 | 0.0001 | 441 ± 59 | 54 ± 14 | 0.0001 | 579 ± 80 | 56 ± 14 | 0.0001 | 94 ± 23 | 3 ± 1.5 | 0.0006 |
C57BL/6 | n = 15,15 | 7276 ± 637 | 1197 ± 162 | 0.0001 | 540 ± 41 | 129 ± 14 | 0.0001 | 626 ± 59 | 102 ± 13 | 0.0001 | 136 ± 17 | 6 ± 1.3 | 0.0001 |
Five groups of mice consisting of wild-type 129/SvEv, F2−/−, F2+/−, F2+/+, and wild-type C57BL/6 were randomized and injected intraperitoneally with saline or 0.6 mg/kg haloperidol and 15 min later placed in an open field for automated measurement of locomotor parameters over a 30 min test period. For each group n, saline subjects, haloperidol subjects. Data are mean ± SEM. p values were from ANOVA followed by Tukey post hoc analysis of drug effect within genotype. NS, Not significant.