Average paw withdrawal latencies from a heat source after SCH-23390 in the RAIC
| Dose of SCH-23390 | Onsite | Offsite | Vehicle | |||
|---|---|---|---|---|---|---|
| n | Average time (sec) | n | Average time (sec) | n | Average time (sec) | |
| 0.24 nmol | ||||||
| ipsilateral | 8 | 3.2 ± 0.03 | 4 | 3.3 ± 0.03 | 4 | 3.3 ± 0.03 |
| contralateral | 3.2 ± 0.02 | 3.3 ± 0.05 | 3.3 ± 0.02 | |||
| 1.2 nmol | ||||||
| ipsilateral | 6 | 3.2 ± 0.01 | 5 | 3.6 ± 0.01 | 4 | 3.6 ± 0.06 |
| contralateral | 3.1 ± 0.07* | 3.5 ± 0.02 | 3.5 ± 0.04 | |||
| 6.0 nmol | ||||||
| ipsilateral | 5 | 4.8 ± 0.2 | 9 | 4.2 ± 0.06 | 4 | 3.8 ± 0.2 |
| contralateral | 5.5 ± 0.2* | 4.4 ± 0.06 | 3.7 ± 0.04 | |||
* Significantly different from both offsite and vehicle injected on the same side (p < 0.05).