Table 1.

Morphological analysis of CA1 synapses in BDNF mutant mice

DV/μmL(μm)DVA(μm2)ADV(μm2)TDV
CD1/BDNF
 +/+3.84  ± 0.110.86  ± 0.033.2  ± 0.120.580.079.3
 +/−2.49  ± 0.07*0.93  ± 0.022.2  ± 0.8*0.680.174.5
 −/−2.15  ± 0.06*0.92  ± 0.021.9  ± 0.7*0.660.223.4
BL/6/BDNF
 +/+1.86  ± 0.120.71  ± 0.0333.37  ± 0.210.390.0410.3
 +/−1.40  ± 0.09*0.81  ± 0.0322.40  ± 0.18*0.510.115.2
  • DV, Number of docked vesicles per active zone;L, active zone length (μm); DV/μm, number of docked vesicles per micrometer of active zone length,DV/μm = DV/L; A, total active zone area (μm2), A = 1/4 · π · L2; ADV, active zone area per docked vesicle, ADV = (L/DV)2; TDV, total number of docked vesicles per whole active zone, TDV =A/(0.866 · ADV). DV/μm,L, and DV are average numbers measured from 247–315 single sections of electron micrographs (mean ± SEM). Data from +/− and −/− were compared with those of +/+, and statistical differences were assessed by ANOVA test. *p< 0.005.