Table 1.

IL-6 induction in human astrocytes and CRT cells by TNF-α and the sIL-6R

Cell treatment1-aIL-6 bioactivity (pg/ml)
AstrocytesCRT
Medium0.6  ± 0.41-b1.3  ± 0.11-b
sIL-6R (100 ng/ml)2.0  ± 0.93.2  ± 0.6
TNF-α (50 ng/ml)221.6  ± 37.3244.4  ± 76.7
TNF-α + sIL-6R29,793.4  ± 10,568.0c,*1,626.7  ± 345.1c,**
  • F1-a Twenty-four hour incubation period.

  • F1-b Mean ± SD of triplicate samples from two experiments analyzed in triplicate.

  • F1-c Significance between experimental values was determined by two-way ANOVA: *p < 0.05; **p < 0.01.