Table 1.

Spontaneous 3H-DA release in U69,593-exposed cultures after U69,593 washout

Exposure time (hr)3H-DA release (n)
024.4  ± 0.4  (6)
425.8  ± 0.4  (6)*
14427.9  ± 0.4  (6)**#

  • Cultures were kept naïve or were exposed to 1 μmU69,593 for 4 or 144 hr. Medium was removed, and the cultures were washed with U69,593-free KRS in preparation for 3H-DA load according to the standard release assay protocol. Spontaneous release was measured at 30 min post-load for each of the U69,593 exposure conditions. Release is expressed as a percentage of total uptake ±SEM. *p < 0.05 (vs 0 hr exposure); **p < 0.001 (vs 0 hr exposure);

  • p < 0.01 (vs 4 hr exposure).