Table 2.

The left columns show the pain tolerance baseline on day 1 in all experimental groups and the comparisons with the natural history group on day 1 (p levels). The right columns show the pain tolerance on the day after drug administration and its comparison with pain tolerance on day 1

GroupPain tolerance baseline on day 1 (min)Comparison with natural history on day 1 (ANOVA)Pain tolerance on the day after experimental test (min)Comparison with day 1 (ANOVA)
 213.32  ± 4.2F(1,79)= 0.26; p = 0.612(day 3) 13.24  ± 3.03F(1,24)= 0.01; p = 0.910
 314.12  ± 4.38F(1,70) = 0.04; p = 0.838(day 3) 13.87  ± 3.83F(1,15) = 0.33; p = 0.572
 413.33  ± 4.25F(1,69) = 0.17; p = 0.683(day 3) 12.53  ± 3.64F(1,14) = 2.09; p = 0.171
 512.77  ± 4.13F(1,67) = 0.64; p = 0.427(day 5) 12.92  ± 2.9F(1,12) = 0.03; p = 0.862
 612.14  ± 4.49F(1,68) = 1.64; p = 0.204(day 5) 11.71  ± 4.43F(1,13) = 0.40; p = 0.538
 713.57  ± 3.72F(1,68) = 0.05; p = 0.824(day 5) 13.43  ± 3.11F(1,13) = 0.04; p = 0.842
 813.69  ± 4.27F(1,70) = 0.02; p = 0.893(day 5) 13.19  ± 4.02F(1,15) = 0.48; p = 0.497
 914.35  ± 4.14F(1,71) = 0.16; p = 0.690(day 5) 13.71  ± 3.33F(1,16) = 1.39; p = 0.256
1013.27  ± 3.77F(1,69) = 0.22; p = 0.643(day 5) 12.67  ± 3.29F(1,14) = 0.93; p = 0.352
1113.86  ± 4.07F(1,68) = 0.00; p = 0.999(day 5) 13.21  ± 3.72F(1,13) = 0.84; p = 0.375
1212.86  ± 4.24F(1,68) = 0.57; p = 0.454(day 5) 12.29  ± 3.22F(1,13) = 0.55; p = 0.470