Properties of α,β-methylene-ATP concentration–effect curves with and without IVM on P2X4 receptors alone or when expressed in combination with P2X6 receptors
Receptor | α,β-Methylene-ATP | Threshold (μm) | EC50 (μm) | Hill slope | Imax(−nA)1-a | n |
---|---|---|---|---|---|---|
P2X4 | Control | 300 | >300 | 1-b | 433 ± 113 | 7 |
+IVM (3 μm) | 10 | 19.8 ± 3.7 | 2.0 ± 0.2 | 1608 ± 311 | 6 | |
P2X4/P2X6 | Control | 10 | 25.1 ± 2.7* | 1.8 ± 0.3 | 360 ± 50 | 8 |
+IVM (3 μm) | 3 | 15.6 ± 1.4* | 2.2 ± 0.1 | 3739 ± 244 | 9 |