Table 3.

Retinal degeneration loci in zebrafish

GeneAllelePhR defect (visible at 6 dpf)RPE defect (visible at 6 dpf)Other cell types or tissues affected3-a
blassblstg306aNoYesMelanophores (8, renamed in this paper)
bleachedblcth204bNoYesMelanophores, ear, CNS (3, 6, 8, 14)
blurredblrtx3cNoYesMelanophores (6, 8)
fade outfadtm63cYesYesMelanophores (6, 8)
fading visionfdvth236aYesYesMelanophores, CNS (3, 5, 8)
miragemirtm79dNoYesMelanophores (6, 8)
ivoryIvytm271aYesYesMelanophores, CNS (3, 6, 8)
quasimodoqamtb244cNoYesMelanophores, notochord (8, 9)
sunbleachedsblto4aYesYesMelanophores, jaw, branchial arches (6, 8, 12)
crocodilecrotw212dYesNoOther neurons (4)
flatheadflata53cYesNoCNS, jaw and branchial arches (6, 8, 12)
tp49dNNtp49dCentral retinaNoKidney (1, 2)
tz288bNNtz288bCentral retinaNoKidney (1, 2)
  • Defects in the outer retina are visible histologically at 6 dpf. All mutants are behaviorally blind or visually impaired and have defective ERG responses (no or reduced a-wave).

  • F3-a References: 1, Brand et al. (1996); 2, Chen et al. (1996); 3, Furutani-Seiki et al. (1996); 4, Granato et al. (1996); 5, Haffter et al. (1996b); 6, Heisenberg et al. (1996); 8, Kelsh et al. (1996); 9, Odenthal et al. (1996a); 12, Schilling et al. (1996); 14,Whitfield et al. (1996).