Table 1.

Effects of drugs treatments on LTP and LFS-induced depotentiation at hippocampal CA1 synapses

Drug treatmentLTP 40 min after TSThe residual LTP 40 min after LFS following TS
Control136.6  ± 6.8% (n = 12)*111.3  ± 6.7% (n = 10)
Probenecid (200 μm)134.8  ± 5.6% (n = 6)*132.0  ± 4.8% (n = 10)*
Ro 20-1724 (200 μm)157.6  ± 7.4% (n = 7)*169.4  ± 5.3% (n = 6)*
AOPCP (200 μm)135.8  ± 4.7% (n = 6)*127.1  ± 6.8% (n = 6)*
+GMP (2 mm)
FPL 67156 (100 μm)130.7  ± 4.9% (n = 6)*103.4  ± 6.8% (n = 6)
  • The data represent the percentage of baseline for fEPSP slope. Number of experiments is in parentheses.

  • *Significantly different from baseline (Student t test;p < 0.05).