Table 3.

Hippocampal content of 5-HT and 5-HIAA (ng/gm wet weight of tissue)

Treatment5-HT5-HIAA
Control (n = 10)180  ± 83-a191  ± 7
Paroxetine (10 mg) (n = 5)199  ± 12222  ± 11
Paroxetine (5 mg) (n = 6)208  ± 17188  ± 12
Sertraline (n = 4)205  ± 14210  ± 13
  • F3-a Mean ± SEM.

  • Rats were chronically treated with paroxetine, sertraline, or vehicle. Hippocampi were processed for 5-HT and 5-HIAA content. Chronic treatment with SSRIs did not alter the content of serotonin or its metabolite in hippocampus.