Table 1.

Kinetic parameters of GABA-mediated currents

Rise time (msec)τ1(msec)% (τ1)τ2(msec)τmoy or τe (msec)n
mIPSCs1-a0.81  ± 0.161-b8.7  ± 2.266  ± 1227  ± 1413.0  ± 3.318
10 mm0.40  ± 0.111-b5.0  ± 2.148  ± 895  ± 5553  ± 2410
1 mm0.57  ± 0.173.1  ± 0.958  ± 9109  ± 3647  ± 1415
1 mm (+30 mV)0.60  ± 0.145.8  ± 4.052  ± 1491  ± 1943  ± 165
300 μm0.76  ± 0.121-b3.3  ± 1.264  ± 11105  ± 2239  ± 96
100 μm0.84  ± 0.201-bn.d.n.d.n.d.35  ± 71-c6
  • n.d., Not determined.

  • F1-a The values are different from the text, because they result from the fit of the average mIPSCs.

  • F1-b Significantly different from the rise time of 1 mm GABA-elicited currents (p < 0.01).

  • F1-c The responses to 100 μm GABA were too small to be reliably fitted with exponentials. Therefore we used τe to quantify their decay kinetics. It is significantly (unpaired t test, p < 0.05) shorter that the decay of 1 mm GABA-elicited currents.