Table 1.

Percentage of slices with DC negative shifts and recovery of EPSPs after oxygen and glucose deprivation (OGD)

Experimental conditionPercentage of slices with DC negative shift (n)Onset of DC negative shift (n)Evoked EPSP (percentage of initial EPSP amplitude)
Control0  (0/9)1-a110  ± 111-c
OGD (2 min)33  (2/6)1.0  (2)1-b
OGD (5 min)67  (4/6)1.5  ± 0.5  (4)
OGD (12 min)100  (5/5)4.75  ± 1.3  (5)
OGD (42 min)100  (8/8)5.00  ± 1.9  (8)
OGD/ROX-36°C100  (6/6)5.9  ± 0.75  (6)16  ± 8.5
OGD/ROX-31°C43  (7/7)8.5  ± 0.76  (3)65  ± 16
  • F1-a Ratio in parentheses is number of slices exhibiting DC negative shift per total number of slices in experimental group.

  • F1-b Onset (mean minutes of oxygen/glucose deprivation ± SEM) of DC negative shift for those slices (n) exhibiting a shift during the OGD period. See Materials and Methods for electrophysiological protocol.

  • F1-c Differences among treatment and control groups were statistically significant (p < 0.05; Kruskal–Wallis on rank ANOVA with Bonferroni correction).