Peak fear
Context | Tone | ||
---|---|---|---|
Experiment 1 | |||
Remote | |||
Sham | 95.8 ± 2.0 | 75.8 ± 8.2 | p = 0.02* |
DH | 96.6 ± 2.4 | 75.0 ± 11.7 | p = 0.2 |
p > 0.6 | p > 0.9 | ||
Recent | |||
Sham | 95.8 ± 1.6 | 80.0 ± 6.3 | p = 0.01* |
DH | 71.6 ± 8.4 | 71.6 ± 12.5 | p > 0.99 |
p = 0.02* | p > 0.9 | ||
Experiment 2 | |||
Sham | 99.3 ± 0.7 | 84.0 ± 7.6 | p = 0.03* |
DH | 79.7 ± 9.1 | 92.2 ± 4.7 | p = 0.2 |
p < 0.01* | p > 0.8 |
Peak freezing (mean ± SEM) was computed by taking each rat’s maximum freezing for any continuous minute during each of the 8-min context and 6-min (post-baseline) tone fear tests. Paired comparisons contrast context and tone freezing within-subjects using the Wilcoxon signed-rank post hoc; unpaired comparisons contrast Sham and DH groups for each test using the Mann–Whitney U post hoc. For both Experiments 1 and 2, DH lesions produced significant impairments in average (Figs. 3-5) and peak (above) recent context fear but not remote context or tone fear. For Sham animals, peak (above) and average (Figs. 3-5) context fear was greater than, or equivalent to, but not weaker than tone fear.