Experimental protocols
| Animal | Region of M1 injected | Virus titer (pfu/ml) | # of surface penetrations | #of sulcal penetrations | Total # of injections | Total volume injected (μl) | Survival period (d) |
|---|---|---|---|---|---|---|---|
| Z10 | Arm | 6.1 × 108 | 2 | 2 | 8 | 0.40 | 4.5 |
| Jo 19 | Arm | 8.2 × 108 | 7 | 4 | 19 | 0.95 | 4.7 |
| Jo 201-a | Arm | 3.6 × 1010 | 4 | 4 | 16 | 0.80 | 4.8 |
| Jo 17 | Leg | 8.2 × 108 | 9 | 0 | 9 | 0.45 | 4.8 |
| Jo 18 | Face | 8.2 × 108 | 9 | 0 | 9 | 0.45 | 4.6 |
| Jo 25 | Arm | 8.2 × 108 | 4 | 4 | 16 | 0.80 | 2.0 |
| Jo 26 | Arm | 8.2 × 108 | 4 | 4 | 16 | 0.80 | 3.0 |
| Jo 21 | Arm | 8.2 × 108 | 8 | 4 | 20 | 1.0 | 7.0 |
↵F1-a This animal was injected with a modified strain of McIntyre-B HSV-1. See Materials and Methods.