Table 1.

K+ current inhibition in transfected cells

CellsTreatmentI/I0n
Kv2.1 in COS3 nm KC IgG53.1  ± 12.33
Kv2.2 in COS3 nm KC IgG107.6  ± 4.9b3
Kv1.5 in COS3 nm KC IgG100.3  ± 8.7b5
drk1CGN/L(tk−)Control100.2  ± 7.55
drk1CGN/L(tk−)3 nm KC IgG46.9  ± 10.2a4
  • F1-a p < 0.005 versus control.

  • F1-b p < 0.05 versus Kv2.1 in COS + KC.

  • Cells were maintained at a holding potential of −80 mV and depolarized to +20 mV for 200 msec once per minute. Currents at 10 min were expressed as a percentage of the current at time zero (I/I0).