Table 3.

K+ current inhibition in hippocampal neurons

TreatmentI/I0n
Control97.2  ± 2.14
3 nm KC IgG56.4  ± 6.63-a5
3 nm Kv1.4E IgG99.0  ± 2.94
200 nm Kv4.2C IgG99.4  ± 2.94
3 nm KC IgG plus pGEX-KC90.1  ± 4.34
3 nm KC IgG plus pGEX-drk156.9  ± 4.93-a2
  • F3-a p < 0.005 versus control.

  • Cells were maintained at a holding potential of −30 mV and depolarized to +20 mV for 200 msec once per minute. Currents at 10 min were expressed as a percentage of the current at time zero (I/I0).