Table 2.

Gain-of-function mutations in the deg-1 gene cause ASH degeneration

GenotypeDye filling (% defective)
N2 (wild type)0  (n = 30)
deg-1(u38)27  (n = 15)
deg-1(u38); mec-60  (n = 37)
deg-1(u506)73  (n = 15)
deg-1(u506u550)0  (n = 39)
unc-8(n491)0  (n = 10)
unc-8(n491n1193)0  (n = 24)
  • ASH degeneration was assessed by dye filling with DiO. The number of neurons scored (n) is indicated. Swollen, degenerating ASH neurons were detected in dye-filling defective strains.