Table 2.

Effect of nicotine on the average firing frequency of submucosal neurons

Preparation #Record #Cell# of spikesDuration (sec)Avg. frequency (Hz)
Control
 11 (R)A891800.49
B671800.37
C1031800.57
D111800.06
E51800.03
F1131800.63
G831800.46
H741800.41
 21 (G)A21200.02
B601200.50
 31 (G)A1191800.66
B361800.20
C271800.15
D301800.17
E131800.07
 41 (G)A9600.15
B5600.08
 51 (G)A731200.61
2 (G)A301800.17
B451800.25
C1161800.64
D251800.14
E701800.39
3 (G)A231800.13
B1121800.62
C11800.01
D101800.06
4 (G)A1631401.16
B91400.06
5 (G)A441200.37
B11200.01
C101200.08
6 (G)A121801.51
 61 (G)A61200.05
B51200.04
C191200.16
D201200.17
E91200.08
2 (G)A341000.34
B1231001.23
3 (G)A18900.20
B97901.08
C3900.03
D25900.28
E35900.39
4 (G)A281400.20
B121400.09
C721400.51
D551400.39
E251400.18
F41400.03
G61400.04
Average firing frequency: 0.32 Hz
% of active cells with average firing frequency ≤0.5 Hz: 79%
% of active cells with average firing frequency between 0.5 and 1H.0 Hz: 13%
% of active cells with average firing frequency between 1.0 and 1.5 Hz: 6%
% of active cells with average firing frequency between 1.5 and 2.0 Hz: 2%
% of active cells with average firing frequency ≥2.0 Hz: 0%
Preparation #Record #Cell# of spikesDuration (sec)Avg. frequency (Hz)
Acute nicotine
 11 (G)A191800.11
B301800.17
C31800.02
D41800.02
E5441803.02
 21 (G)A54800.68
B90801.13
C190802.38
D6800.08
E1800.01
F1800.01
G23800.29
H12800.15
 31 (G)A2400.05
B14400.35
C116402.90
D10400.25
E30400.75
F3400.08
G41401.03
H30400.75
I21400.53
J37400.93
2 (G)A272604.53
B217603.62
C17600.28
 41 (R)A3350.09
B75352.14
C77352.20
D57351.63
E6350.17
F58351.66
G87352.49
H58351.66
I111353.17
J50351.43
2 (G)A6450.13
B7450.16
C8450.18
D2450.04
E75451.67
F7450.16
G76451.69
H300456.67
I130452.89
J43450.96
Average firing frequency: 1.20 Hz
% of active cells with average firing frequency ≤0.5 Hz: 44%
% of active cells with average firing frequency between 0.5 and 1H.0 Hz: 13%
% of active cells with average firing frequency between 1.0 and 1.5 Hz: 7%
% of active cells with average firing frequency between 1.5 and 2.0 Hz: 11%
% of active cells with average firing frequency ≥2.0 Hz: 25%
Chronic nicotine
 11 (G)A42600.70
B6600.10
C1600.02
D2600.03
Preparation #Record #Cell# of spikesDuration (sec)Avg. frequency (Hz)
Chronic nicotine
 21 (G)A84601.40
B16600.27
C85601.42
2 (G)A45600.75
B43600.72
C11600.18
D30600.50
 31 (G)A111000.11
B611000.61
C631000.63
D861000.86
E251000.25
F171000.17
G71000.07
2 (G)A75601.25
3 (G)A57600.95
B27600.45
C5600.08
4 (G)A32600.53
B14600.23
C26600.43
D40600.67
E99601.65
 41 (G)A1322100.63
B1222100.58
C612100.29
2 (G)A49600.82
B6600.10
C2600.03
D17600.28
3 (G)A41300.03
B1091300.84
4 (G)A69601.15
B31600.52
C11600.18
D29600.48
E2600.03
F1600.02
5 (G)A71601.18
B14600.23
C1600.02
 51 (G)A101500.07
B321500.21
C21500.01
2 (G)A11600.18
B7600.12
C42600.70
D14600.23
3 (G)A11200.01
B141200.12
C1161200.97
D1151200.96
E771200.64
Average firing frequency: 0.57 Hz
% of active cells with average firing frequency ≤0.5 Hz: 58%
% of active cells with average firing frequency between 0.5 and 1H.0 Hz: 30%
% of active cells with average firing frequency between 1.0 and 1.5 Hz: 9%