Effect of sumatriptan on calcium levels in cultured trigeminal neurons
| Sample | n | Basal (nm) | Peak (nm) | Fold increase | Peak time (sec) |
|---|---|---|---|---|---|
| Control | 11 | 119 ± 5 | 129 ± 73-a | 1.1 ± 0.83-a | a |
| Sumatriptan | 15 | 113 ± 7 | 621 ± 53* | 5.5 ± 0.6 | 488 ± 27 |
Intracellular calcium levels were measured from untreated control neurons or neurons treated with 10 μm sumatriptan. The means and SE are given.
*p < 0.001 when compared with control levels.
↵F3-a There was no significant change in calcium in control cells, so for comparison with the sumatriptan-treated cells, calcium levels at 488 sec were used to calculate peak and fold increase values for the control cells.