cAMP levels in cultured trigeminal neurons
| Sample | cAMP (fmol/dish) | Fold increase |
|---|---|---|
| Control | 354 ± 25 | |
| FSK | 11283 ± 916* | 32 |
| FSK + sumatriptan | 10930 ± 1029 | 31 |
| FSK + CGS | 11047 ± 720 | 31 |
| IFC | 364 ± 10 | 1.0 |
| IFC + sumatriptan | 356 ± 18 | 1.0 |
cAMP levels were measured from untreated control cultures or cells treated for 30 min with forskolin (FSK) or with a cocktail of inflammatory agents (IFC). The cultures were cotreated with vehicle, sumatriptan, or CGS. The means and SE from five independent experiments with duplicate samples, and the fold increases in cAMP levels relative to control cells are shown.
*p < 0.001 when compared with control levels.