Table 1.

IC50 or % of control steady-state current

BlockerBasket cell soma (whole-cell patch)Basket cell terminal (whole-cell patch)Purkinje cell soma (outside-out patch)
TEA206 μm (outside-out) (n = 5)170 μm/25 mm (n = 10)173 μm (n = 6)
4-APne 5 mm (n = 4)1-a8 μm/7.8 mm (n = 7)271 μm (n = 6)
α-DTXne 200 nm (n = 5)1-a3.2 nm (n = 6)ne 200 nm (101.6 ± 1.6%; n = 3)
Toxin Kne 200 nm (n = 4)1-a56% of control (200 nm; n = 1)ne 200 nm  (98.3 ± 3.2; n = 3)
γ-DTXne 200 nm (94.1 ± 1.7%; n = 3)50% of control (200 nm; n = 1)ne 200 nm  (97.6 ± 1.9%; n = 4)
Toxin Ine 200 nm1-a ne 300 nm1-a (n = 4)ne 200 nm  (92.5 ± 4.1%; n = 3)
Apaminne 1 μm1-a (n = 3)ne 1 μm (93.4 ± 4.5%;n = 4)
CbTxne 100 nm (n = 4)1-ane 100 nm  (98.5 ± 4.0%; n = 3)
MgTxne 10 nm (96.6 ± 5.3%; n = 3)ne 10 nm  (94.1 ± 5.6%; n = 3)
AgTx-2ne 10 nm (96.4 ± 2.0%; n = 3)ne 10 nm (104.1 ± 4.1%, n = 3)
  • F1-a See Southan and Robertson (1998a).