Amino acid consensus sequences for two subgroups in the lipophilin family
| Lipophilin group | Protein | Amino acid sequences of second extracellular domains | |||||
|---|---|---|---|---|---|---|---|
| A | hDM-20/hM6b | W | C | CΦD | PWNAFPGK Φ CG | C | |
| DMα/DMγ | W | C | CVD | PWNASPGK Φ CG | C | ||
| Consensus* | W X2 | C X16–17 | CΦD X7 | PWNA PGK Φ CG | X6 | C | |
| B | hM6a | W | C | CLD | TIGEEKKIC | C | |
| DMβ | W | C | CFD | PIHEQKTVC | C | ||
| sM6a | W | C | CID | VKQEDMKIC | C | ||
| dM6a | W | C | CID | TKLEDMKVC | C | ||
| Consensus* | W X2 | C X8–11 | CΦD X7–11 | E. ΦC | X8–9 | C | |
*Single-letter codes are used to specify amino acids; X denotes any amino acid; Φ denotes an hydrophobic amino acid. DM-20/PLP, M6a, and M6b sequences are from human; DMα, DMβ, and DMγ sequences are from Squalus acanthias; dM6a sequence is fromDrosophila melanogaster; sM6a sequence is from the silkworm,Bombyx mori.