Table 1.

Influence of chronic fluoxetine administration on CRE-mediated gene expression

β-Galactosidase expression
SALFLU
Amygdala173  ± 15217  ± 11*
Cortex196  ± 17241  ± 9*
CA3138  ± 4184  ± 17*
Dentate gyrus135  ± 7141  ± 12
Hypothalamus125  ± 8167  ± 8*
Thalamus120  ± 4152  ± 14*

  • Mice received a chronic (14 d) administration of vehicle (SAL) or fluoxetine (FLU) and were killed 6 h after the last injection. Levels of β-galactosidase were determined by immunohistochemistry as described in Materials and Methods. Levels of β-galactosidase labeling were quantified by densitometry of digitalized images as described in Materials and Methods. The data are the mean ± SEM;n = 6 separate determinations. *p < 0.05 compared with saline (Kruskal–Wallis).