Table 4.

Influence of acute antidepressant administration on levels of phospho-CREB immunohistochemistry

Phospho-CREB
SALFLUDMI
Amygdala1.8  ± 0.31.9  ± 0.11.1  ± 0.3
Cortex0.5  ± 0.30.3  ± 0.20.0  ± 0.0
CA10.0  ± 0.00.0  ± 0.00.0  ± 0.0
CA30.0  ± 0.00.0  ± 0.00.0  ± 0.0
Dentate gyrus0.3  ± 0.21.0  ± 0.31.1  ± 0.2
Hypothalamus2.0  ± 0.31.9  ± 0.12.1  ± 0.1
Thalamus0.6  ± 0.21.1  ± 0.10.8  ± 0.2
  • Mice received a single dose of vehicle (SAL), fluoxetine (FLU), or desipramine (DMI) and were killed 6 h later. Levels of phospho-CREB were determined by immunohistochemistry as described in Materials and Methods. The data are the mean ± SEM;n = 4–5 separate determinations. *p < 0.05 compared with saline (Kruskal–Wallis).