Peaks, kinetics, and integrals of miniature EPSCs
| Rise time (msec) | Peak (pA) | Decay (msec) | Integral (pC) | n | |
|---|---|---|---|---|---|
| WT | 1.3 ± 0.1 | −13.0 ± 1.5 | 9.3 ± 0.9 | 0.21 ± 0.02 | 7 (3) |
| + AP5 | 1.2 ± 0.1 | −9.3 ± 0.4 | 6.1 ± 0.82-159 | 0.07 ± 0.012-214 | |
| ΔC/ΔC | 1.2 ± 0.1 | −14.4 ± 1.6 | 6.5 ± 0.8* | 0.16 ± 0.02 | 7 (3) |
| + AP5 | 1.4 ± 0.2 | −11.3 ± 0.7*2-159 | 6.3 ± 0.6 | 0.10 ± 0.012-159 |
Between genotypes:
↵* p < 0.05; within genotype (control vs AP5):
↵F2-214 p< 0.001,
↵F2-159 p < 0.05.
mEPSCs were recorded in CA1 pyramidal cells in TTX (1 μm), bicuculline (10 μm), and glycine (10 μm) at −70mV in 0.1 mmMg2+. The effect of AP5 (30 μm) was studied in 2-week-old wild-type (WT) and NR2AΔC/ΔC mice. Values are mean ± SEM. Numbers of recorded cells and analyzed animals (in parentheses) are indicated. Statistical significance was weighted by a two-samplet test between wild-type and NR2AΔC/ΔC mice (*) or between control and AP5-containing solution within one genotype (#).