Table 1.

Effects of ZD 7288 on membrane potential and spike discharge

nControl ZD 7288p value
Silent cells
Vm in silent cells held >−65 mV (mV)6 −61.7  ± 1.8 −62.4  ± 1.60.320
Vm in silent cells held ≤−65 mV (mV) 4 −80.8  ± 10.3 −85.0  ± 11.60.048
Continuously active cells
Vm (mV) 6 −57.8  ± 1.1−59.9  ± 1.60.013
Phasically active cells
Vmduring active phase (mV) 5 −57.5  ± 1.0 −61.8  ± 1.9 0.031
 Minimum Vmduring silent phase (mV) 5 −62.8  ± 1.3 −63.0  ± 1.4 0.874
 Steady state frequency (Hz) 5 8.6  ± 1.2 5.1  ± 0.48 0.016
 Burst length (sec) 5 47.0  ± 8.8 10.8  ± 2.7 0.013
 Silent interval (sec) 5 44.8  ± 12.7 53.4  ± 13.6 0.002
  • The table reports the mean (±SEM) effects of ZD 7288 on membrane potential (Vm), steady-state firing frequency, and phasic bursting parameters observed in a number (n) of MNCs. Group values were compared using a paired t test, and the p values are reported. Significant changes (p< 0.05) are noted by the bolded p values.