Table 1.

Outward K⁺ currents in wild-type and transfected SCG neurons^{^1-a}

Phenotype		Wild type			Kv4.2W362F			Kv4.2
Phenotype		Type I	Type II	Type III	A	B	C	Type I	Type II
Peak current density		252 ± 20	259 ± 22	211 ± 18	162 ± 21	289 ± 31	244 ± 35	249 ± 27	291 ± 37
I_Af	density (pA/pF)	81 ± 11	111 ± 21				64 ± 20	127 ± 9^{^1-213}	136 ± 16^{^1-213}
	τ (msec)	121 ± 14	95 ± 8				190 ± 18	87 ± 10	70 ± 8
I_As	density (pA/pF)		45 ± 3			67 ± 15			57 ± 21
	τ (msec)		480 ± 21			490 ± 31			472 ± 8
I_K	density (pA/pF)	108 ± 12	64 ± 9^*	136 ± 11	111 ± 22	157 ± 25^1-160	115 ± 7	78 ± 17^{^1-214}	67 ± 2
	τ (msec)	2560 ± 187	2800 ± 193	2200 ± 176	2050 ± 235	2473 ± 254	2368 ± 197	2126 ± 518	2151 ± 195
I_SS	density (pA/pF)	74 ± 5	45 ± 5^*	79 ± 6	65 ± 9	72 ± 15	68 ± 15	40 ± 6^{^1-214}	38 ± 17
n		30	9	4	18	7	6	11	5

↵* I_K andI_SS densities are significantly (p < 0.005) lower in wild-type Type II than in either wild-type Type I or III cells.
↵F1-160 I_Kdensity is significantly (p < 0.002) higher in Kv4.2W362F-expressing cells than in wild-type Type II cells.
↵F1-213 I_Af density is significantly (p < 0.04) greater in Kv4.2-expressing cells than in wild-type Type I or II cells.
↵F1-214 I_K andI_SS densities are also significantly (p < 0.005) lower in Kv4.2-expressing cells than in wild-type Type I cells (Table 1).
↵F1-a All values are mean ± SEM; current densities determined at +50 mV; n = number of cells.