Table 1.

Outward K+ currents in wild-type and transfected SCG neurons 1-a

PhenotypeWild typeKv4.2W362FKv4.2
Type IType IIType IIIABCType IType II
Peak current density252  ± 20259  ± 22211  ± 18162  ± 21289  ± 31244  ± 35249  ± 27291  ± 37
IAfdensity (pA/pF)81  ± 11111  ± 2164  ± 20127  ± 91-213136  ± 161-213
τ (msec)121  ± 1495  ± 8190  ± 1887  ± 1070  ± 8
IAsdensity (pA/pF)45  ± 367  ± 1557  ± 21
τ (msec)480  ± 21490  ± 31472  ± 8
IKdensity (pA/pF)108  ± 1264  ± 9*136  ± 11111  ± 22157  ± 251-160115  ± 778  ± 171-21467  ± 2
τ (msec)2560  ± 1872800  ± 1932200  ± 1762050  ± 2352473  ± 2542368  ± 1972126  ± 5182151  ± 195
ISSdensity (pA/pF)74  ± 545  ± 5*79  ± 665  ± 972  ± 1568  ± 1540  ± 61-21438  ± 17
n30941876115
  • * IK andISS densities are significantly (p < 0.005) lower in wild-type Type II than in either wild-type Type I or III cells.

  • F1-160 IKdensity is significantly (p < 0.002) higher in Kv4.2W362F-expressing cells than in wild-type Type II cells.

  • F1-213 IAf density is significantly (p < 0.04) greater in Kv4.2-expressing cells than in wild-type Type I or II cells.

  • F1-214 IK andISS densities are also significantly (p < 0.005) lower in Kv4.2-expressing cells than in wild-type Type I cells (Table 1).

  • F1-a All values are mean ± SEM; current densities determined at +50 mV; n = number of cells.