Table 4.

Overexpression of Kv4.2 reduces the input resistance and the number of adapting neurons 4-a

PhenotypeRin(GΩ)Vm (mV)APThresh(pA)APA (mV)APD50 (msec)APD90(msec)n
All cells0.35  ± 0.05−52  ± 143  ± 492  ± 22.78  ± 0.104.87  ± 0.1728
Phasic0.23  ± 0.03−52  ± 158  ± 989  ± 32.87  ± 0.154-1605.05  ± 0.254-15010
Adapting0.46  ± 0.074-213−51  ± 239  ± 44-15086  ± 23.03  ± 0.205.28  ± 0.244
Tonic0.29  ± 0.04−51  ± 145  ± 495  ± 22.70  ± 0.194.75  ± 0.2414
  • F4-150 ,

  • F4-160 Values are significantly different from those in wild-type cells at the p < 0.003* and p < 0.001** levels.

  • F4-213 Values are significantly (p < 0.005) different from those in phasic cells.

  • F4-a All values are means ± SEM.