Strain | Postoperative survival (d) | Motoneuron numbers | SD | Survival IL/CL (%) | ||
---|---|---|---|---|---|---|
LEW.RT1(av1) | 20 | VRA | IL | 77 | 7.3 | 40 |
CL | 193 | 7.1 | ||||
EAE + VRA | IL | 101 | 9 | 54 | ||
CL | 187 | 11.3 | ||||
DA.RT1(av1) | 10 | VRA | IL | 93 | 5.7 | 48 |
CL | 195 | 22 | ||||
EAE + VRA | IL | 136 | 7.2 | 71 | ||
CL | 191 | 15.6 | ||||
20 | VRA | IL | 38 | 5.6 | 19 | |
CL | 205 | 13.3 | ||||
EAE + VRA | IL | 81 | 8.1 | 41 | ||
CL | 198 | 10.1 |
The survival is significantly increased after concomitant EAE (p < 0.05, Mann–Whitney U test) in both the LEW and DA strains. The difference in motoneuron survival after VRA alone between the LEW and DA strains concurs with our previous observations regarding a genetic influence on the degree of motoneuron degeneration in this lesion model (see Results). n = 4 animals in each group. IL, ipsilateral; CL, contralateral.