Parameters of χm(V) and ΔL(V) relationships for the control group of OHCs and the cells preincubated with okadaic acid (1 μm), trifluoperazine (30 μm), and W-7 (150 μm)
| Capacitance measurements | Electromotility measurements | ||||||
|---|---|---|---|---|---|---|---|
| χmax(μF/cm2) | C0(pF) | Vp (mV) | W(mV) | ΔLmax(%) | Vp (mV) | W (mV) | |
| Control (n = 14) | 1.81 ± 0.10 | 22.9 ± 1.5 | −34.8 ± 3.6 | 26.6 ± 0.8 | 2.5 ± 0.6 | −34.7 ± 5.0 | 24.6 ± 1.1 |
| Okadaic acid (n = 6) | 1.82 ± 0.10N | 20.4 ± 1.1N | −60.2 ± 5.21-165 | 30.7 ± 1.71-165 | 3.2 ± 0.6N | −56.5 ± 6.21-160 | 27.6 ± 2.0N |
| Trifluoperazine (n = 6) | 1.63 ± 0.07N | 22.9 ± 1.9N | −6.5 ± 4.21-165 | 27.3 ± 2.4N | 2.4 ± 0.4N | −4.0 ± 5.01-160 | 24.1 ± 4.1N |
| W-7 (n = 7) | 1.75 ± 0.31N | 25.9 ± 3.4N | 4.7 ± 2.31-165 | 26.9 ± 1.8N | 2.8 ± 1.1N | 8.7 ± 6.71-165 | 26.9 ± 1.8N |
Average values and the corresponding SEs are shown. To minimize the potential adverse effects of dialyzing the intracellular constituents with the pipette solution, measurements were taken within 60 sec after establishing whole-cell recording conditions. Statistical significance of the difference between values of any parameter in control and treated OHCs is designated as follows: N, no statistical significance (p > 0.05);
↵F1-160 p< 0.01;
↵F1-165 p < 0.001.