Table 1.

Lack of effect by Ad-NAC administration into the nucleus accumbens on the acute motor response to novelty and psychostimulants

DrugDose (mg/kg, i.p.)Ad-NAC n = 8Ad-lac n = 7
Novelty8636  ± 8548570  ± 358
Saline1766  ± 3031816  ± 329
Morphine3.05774  ± 11756579  ± 1102
Caffeine10.021245  ± 94420944  ± 318
  • All data are shown as the mean (± SEM) distance-traveled photocell counts over 120 min after drug injection, except in rats exposed to novelty in which the data are the distance traveled accumulated over 60 min after placement into the open field. An unpaired, two-tailed Student's t test revealed no significant difference between the Ad-NAC and Ad-lac pretreatment groups.