Distribution patterns of Eph receptors and ephrins within parasagittal domains of Purkinje cells during the middle period of cerebellar development
Zone/lobules | EphA4 | Ephrin-A5 | EphA3 | Ephrin-A2 |
---|---|---|---|---|
Posterior IX | A (lower), B, D | Absent | Homogeneous-EGL | A (higher), B, D |
Figs. 4, 7,9 | Fig. 4 | Figs. 4, 8 | Figs. 4, 7 | |
VIII1-a | A (Lm–Hl), B, D | C, E | Homogeneous-EGL | A (Hm–Ll), B, D |
Figs. 4, 7, 9 | Fig.4, 6 | Figs. 4, 8 | Figs. 4G, 7D | |
Central VI, VII | M, A (lateral), B (Hm–Lc–Hl), D | A1-b (medial), C, E | A (medial), B, D (low) | M, A (medial), B (Lm–Hc–Hl), D |
Figs. 4,6, 7, 9 | Figs. 4C, 6C | Figs. 4, 8 | Figs. 4, 7 | |
Anterior I–V | M, A (lateral), B (medial), D | A (medial), B (lateral), C | Absent (stops at lobule V) | M, A (lateral), B (medial) |
Figs. 4, 6, 7 | Figs. 4, 6 | Fig. 4 | Figs. 4,7 |
Gradients within bands are described only if relevant to the localization of late born cells or the expression of a cognate ligand. M refers to the thin zone bordering the midline in band A (Fig.4B, midline asterisk). EGL, external granule layer; Hm, high medial, Hl, high lateral, Lc, low central, Lm, low medial, Ll, low lateral.
↵F1-a Except for the expression of ephrin-A5, this lobule would be classified as a posterior lobule because the expression pattern of the other molecules is similar to that of lobule IX.
↵F1-b The expression of ephrin-A5 in band A of lobule VII is uncertain.