Table 1.

Caspase-positive oligodendrocyte progenitors infected with AA-Akt or wt-Akt

% Caspase-positive cells
24 hr48 hr
Mock-infect8.9  ± 1.110.4  ± 1.0
AA-Akt50.1  ± 0.41-16055.8  ± 1.01-160
wt-Akt10.5  ± 1.720.0  ± 1.5*
  • Oligodendrocyte progenitor cells were mock-infected or infected with adenovirus expressing AA-Akt or wt-Akt. After a 24 or 48 hr infection, the virus was removed, and cells were cultured in DMEM plus 0.5% FBS for an additional 20–24 hr before caspase inhibitor stain. Caspase-positive cells were counted, and data are expressed as a percentage of total number of cells visualized by DAPI staining. Data are shown as mean ± SEM (n = 3).

  • F1-160 p < 0.0001;

  • * p< 0.0060.