Table 1.

Apparent diffusion coefficient in the left (treated) and right (control) striatum

Time (hr)ADC (×10−4 mm2/sec)
ControlIL-1βNeutrophil depletion and IL-1β
LeftRightLeftRightLeftRight
46.74  ± 0.826.96  ± 0.76
56.63  ± 0.387.15  ± 0.56
67.30  ± 0.257.29  ± 0.215.42  ± 0.35*7.35  ± 0.776.64  ± 0.34*7.49  ± 0.38
276.29  ± 0.35*7.14  ± 0.617.15  ± 0.587.28  ± 0.27
1235.90  ± 0.70*7.10  ± 0.877.10  ± 0.267.13  ± 0.15
  • ADC, Apparent diffusion coefficient measured within a region of interest encompassing the striatum. Control, Injection of 1 μl of vehicle only into the left striatum. IL-1β, Pretreatment with anti-neutrophil serum to deplete animals of neutrophils followed by injection of 1 μl of IL-1β (1 ng/μl) into the left striatum.

  • * Significantly different from control (right hemisphere) by paired t test at that time point (p< 0.05).